Publications
In the following list, * denotes corresponding authorship and † equal contribution.
Published
| 43. Hexafluoroisopropanol-Mediated Cascade Cyclization for Construction of α‑Amino-γ-spirolactones H. Li, F. Huang, C. Miesch, R. J. Mayer, Y. Liu, J. Huang, L. Ma, Z. Zeng, Z. Zhou, D. Lebœuf,* W. Yi,* S. Wang,* JACS Au 2025, early view |
| 42. Harnessing Phenonium Ions in Synthesis R. J. Mayer,* D. Leboeuf,* Angew. Chem. Int. Ed. 2025, 64, e202516932. |
| 41. How Electrophilic Are Keteniminium Ions? T. Siegmund, A. R. Ofial, R. J. Mayer,* H. Mayr,* Synthesis 2025, 57, 3251-3262 (invited contribution). |
| 40. Stepwise or concerted? One-bond-nucleophilicity and -electrophilicity parameters for the mechanistic analysis of 1,3-dipolar cycloadditions H. Mayr,* L. Li, R. J. Mayer, A. R. Ofial, Pure Appl. Chem. 2025, doi: 10.1515/pac-2025-0449 |
| 39. Triflic Acid-Catalyzed Dehydrative Amination of 2-Arylethanols with Weak N-Nucleophiles in Hexafluoroisopropanol M. Van Hoof, R. J. Mayer, J. Moran, D. Leboeuf,* Angew. Chem. Int. Ed. 2025, 54, e202417089. |
| 38. Unraveling C–Selective Ring-Opening of Phosphiranes with Carboxylic Acids and Other Nucleophiles: A Mechanistically-Driven Approach A. Ghosh, T. H. Van Nguyen, C. Bellanger, S. Chelli, M. Ahmad, N. Saffon-Merceron, C. Taillier, V. Dalla, R. J. Mayer, I. M. Dixon, S. Lakhdar,* Angew. Chem. Int. Ed. 2025, 64, e202414172. |
| 37. Measuring Kinetics under Vibrational Strong Coupling: Testing for a Change in the Nucleophilicity of Water and Alcohols C. Muller, R. J. Mayer, M. Piejko, B. Patrahau, V. Bauer, J. Moran,* Angew. Chem. Int. Ed. 2024, 63, e202410770. |
| 36. Coenzymes in a pre-enzymatic metabolism Q. Dherbassy, R. J. Mayer, J. Moran,* Science Advances 2024, 10, eadr5357. |
| 35. Metal Ions Turn on a Stereoselective Nonenzymatic Reduction of Keto Acids by the Coenzyme NADH R. J. Mayer,* J. Moran,* Chem 2024, 10, 2564-2576. – Previously on ChemRxiv. |
| 34. Direct Observation of Polaritonic Chemistry by Nuclear Magnetic Resonance Spectroscopy B. Patrahau, M. Piejko, R. J. Mayer, C. Antheaume, T. Sangchai, G. Ragazzon, A. Jayachandran, E. Devaux, C. Genet, J. Moran,* T.W. Ebbesen,* Angew. Chem. Int. Ed. 2024, 63, e202401368; Angew. Chem. 2024, 136, e202401368. |
| 33. Pyridinium-Derived Mesoionic N-Heterocyclic Olefins (py-mNHOs) Pyridinium-abgeleitete mesoionische N-heterocyclische Olefine (py‑mNHOs) Q. Sun, A. Eitzinger, R. Esken, P. W. Antoni, R. J. Mayer,* A. R. Ofial,* M. M. Hansmann,* Angew. Chem. Int. Ed 2024, 63, e202318283; Angew. Chem. 2024, 136, e202318283. |
| 32. A single phosphorylation mechanism in early metabolism – the case of phosphoenolpyruvate J. Zimmermann, R. J. Mayer, J. Moran,* Chem. Sci. 2023, 14, 14100-14108. |
| 31. Metal/ADP complexes promote phosphorylation of ribonucleotides E. Werner, S. Pinna, R. J. Mayer, J. Moran,* J. Am. Chem. Soc. 2023, 145, 21630-21637. |
| 30. Metal-Pyridoxal Cooperativity in Nonenzymatic Transamination Q. Dherbassy,* R. J. Mayer, K. Muchowska, J. Moran,* J. Am. Chem. Soc. 2023, 145, 13357-13370. |
| 29. NDIPhos as a platform for chiral supramolecular ligands in rhodium-catalyzed enantioselective hydrogenation G. Force, R. J. Mayer, M. Vayer, D. Leboeuf,* Chem. Commun. 2023, 59, 6231-6234. |
| 28. One-Bond-Nucleophilicity and One-Bond-Electrophilicity Parameters: An Efficient Ordering System for 1,3-Dipolar Cycloadditions L. Li, R. J. Mayer, A. R. Ofial,* H. Mayr,* J. Am. Chem. Soc. 2023, 145, 7419-7434. |
| 27. Quantification of the Hydride Donor Abilities of NADH, NADPH and BH3CN– in Water R. J. Mayer,* J. Moran*, Org. Biomol. Chem. 2023, 21, 85-88. |
| 26. Resolving the Mechanistic Complexity in Triarylborane-Induced Conjugate Additions R. J. Mayer,* N. Hampel, A. R. Ofial, H. Mayr, ACS Catal. 2022, 12, 15298–15309. |
| 25. Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis Quantifizierung der Reduktiven Aminierung in Nichtenzymatischer Aminosäuresynthese R. J. Mayer,* J. Moran*, Angew. Chem. 2022, 61, e202212237; Angew. Chem. Int. Ed. 2022, 134, e202212237. |
| 24. Leveraging the Hydroarylation of α-(Trifluoromethyl)styrenes to Access Trifluoromethylated All-Carbon Quaternary Centers M. Vayer, R. J. Mayer, J. Moran, D. Leboeuf,* ACS Catal. 2022, 12, 10995–11001. |
| 23. Quantification of the Electrophilicities of Diazoalkanes: Kinetics and Mechanism of Azo Couplings with Enamines and Sulfonium Ylides L. Li, R. J. Mayer, D. S. Stephenson, P. Mayer, A. R. Ofial,* H. Mayr,* Chem. Eur. J. 2022, e202201376. |
| 22. Hydroarylation of Enamides Enabled by HFIP via a Hexafluoroisopropyl Ether as Iminium Reservoir N. Zeidan,† S. Bicic,† R. J. Mayer,† D. Leboeuf,* J. Moran,* Chem. Sci. 2022, 13, 8436-8443. – Highlighted in Synfacts 2022, 18, 1015 |
| 21. Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue F. R. Traube,* N. F. Brás, W. P. Roos, C. C. Sommermann, T. Diehl, R. J. Mayer, A. R. Ofial, M. Müller, H. Zipse, T. Carell,* Chem. Eur. J. 2022, e202200640. |
| 20. An Overlooked Pathway in 1,3-Dipolar Cycloadditions of Diazoalkanes with Enamines Ein übersehener Reaktionsweg bei 1,3-dipolaren Cycloadditionen von Diazoalkanen mit Enaminen L. Li, P. Mayer, D. S. Stephenson, A. R. Ofial, R. J. Mayer,* H. Mayr,* Angew. Chem. 2022, 134, e202117047; Angew. Chem. Int. Ed., 2022, 61, e202117047. – Selected as Hot Paper |
| 19. Mechanistic Insight into Metal Ion-Catalyzed Transamination R. J. Mayer,† H. Kaur,† S. A. Rauscher, J. Moran,* J. Am. Chem. Soc. 2021, 143, 19099-19111. – Highlighted in JACS Spotlight – Highlighted by C&EN (Nov. 23, 2021) |
| 18. Macrolactonization Reactions Driven by a Pentafluorobenzoyl Group G. Force, A. Perfetto, R. J. Mayer, I. Ciofini,* D. Leboeuf,* Angew. Chem. 2021, 133, 19996-20004; Angew. Chem. Int. Ed.2021, 60, 19843-19851. |
| 17.Quantification of the Lewis Basicities and Nucleophilicities of 1,3,5-Tris(dialkylamino)benzenes G. Micheletti, R. J. Mayer, S. Cino, C. Boga,* A. Mazzanti, A. R. Ofial, H. Mayr,* Eur. J. Org. Chem. 2021, 6347-6357. – Selected as VIP Paper |
| 16. Electrophilic Reactivities of Cyclic Enones and α,β-Unsaturated Lactones R. J. Mayer, P. W. A. Allihn, N. Hampel, P. Mayer, S. A. Sieber, A. R. Ofial,* Chem. Sci. 2021, 12, 4850-4865. |
| 15. Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale R. J. Mayer, N. Hampel, A. R. Ofial,* Chem. Eur. J. 2021, 27, 4070-4080. |
| 14. From Carbodiimides to Carbon Dioxide: Quantification of the Electrophilic Reactivities of Heteroallenes Z. Li, R. J. Mayer, A. R. Ofial, H. Mayr,* J. Am. Chem. Soc. 2020, 142, 8383-8402. |
| 13. Predicting Absolute Rate Constants for Huisgen Reactions of Unsaturated Iminium Ions with Diazoalkanes Voraussage absoluter Geschwindigkeitskonstanten von Huisgen- Reaktionen ungesättigter Iminium-Ionen mit Diazoalkanen J. Zhang,† Q. Chen,† R. J. Mayer,† J.-D. Yang, A. R. Ofial, J.-P. Cheng, H. Mayr,* Angew. Chem. 2020, 132, 12628-12634; Angew. Chem. Int. Ed. 2020, 59, 12527-12533. |
| 12. Electrophilic Reactivities of Vinyl p-Quinone Methides A. Eitzinger,† R. J. Mayer,† N. Hampel, P. Mayer, M. Waser, A. R. Ofial,* Org. Lett. 2020, 22, 2182-2186. |
| 11. Lewis Acidity Scale of Diaryliodonium Ions toward Oxygen, Nitrogen, and Halogen Lewis Bases R. J. Mayer,* A. R. Ofial, H. Mayr, Claude Y. Legault,* J. Am. Chem. Soc. 2020, 142, 5221-5233. |
| 10. Nucleophilicity of Glutathione: A Link to Michael Acceptor Reactivities Nucleophilie von Glutathion als Bindeglied zur Reaktivität von Michael-Akzeptoren R. J. Mayer, A. R. Ofial,* Angew. Chem. 2019, 131, 17868-17872; Angew. Chem. Int. Ed. 2019, 58, 17704-17708. |
| 9. Ambident Reactivity of Phenolate Anions Revisited: A Quantitative Approach to Phenolate Reactivities R. J. Mayer, M. Breugst, N. Hampel, A. R. Ofial,* H. Mayr,* J. Org. Chem. 2019, 84, 8837-8858 – Selected as a Feature Article |
| 8. Biomimetic Approach Toward Enterocin and Deoxyenterocin A. Rizzo, R. J. Mayer, D. Trauner,* J. Org. Chem. 2019, 84, 1162-1175. |
| 7. Synthesis, Structure and Properties of Amino-Substituted Benzhydrylium Ions – a Link Between Ordinary Carbocations and Neutral Electrophiles R. J. Mayer, N. Hampel, P. Mayer, A. R. Ofial,* H. Mayr,* Eur. J. Org. Chem. 2019, 412-421. |
| 6. Intramolecular Hydrogen-Bonding Modulates the Nucleophilic Reactivity of Ammonium-Peroxycarboxylates R. J. Mayer, A. R. Ofial,* Eur. J. Org. Chem. 2018, 6010-6017. |
| 5.Nucleophilic Reactivities of Bleach Reagents R. J. Mayer, A. R. Ofial,* Org. Lett. 2018, 20, 2816-2820. |
| 4.Which Factors Control the Nucleophilic Reactivities of Enamines? D. S. Timofeeva, R. J. Mayer, P. Mayer, A. R. Ofial, H. Mayr,* Chem. Eur. J. 2018, 24, 5901-5910. |
| 3. Solvation Accounts for the Counterintuitive Nucleophilicity Ordering of Peroxide Anions Solvatation als Ursache für die unerwartete Nucleophilie-Reihung von Peroxid-Anionen R. J. Mayer, T. Tokuyasu, P. Mayer, J. Gomar, S. Sabelle, B. Mennucci,* H. Mayr,* A. R. Ofial,* Angew. Chem. 2017, 129, 13463-13467; Angew. Chem. Int. Ed. 2017, 56, 13279-13282. |
| 2. Methoxyphenyl Substituted Bis(picolyl)phosphines and Phosphine Oxides C. Hettstedt, M. Unglert, R. J. Mayer, A. Frank, K. Karaghiosoff,* Eur. J. Inorg. Chem. 2016, 1405-1414. |
| 1. Synthesis of 2-Phosphaindolizine and [1,3]Azaphospholo[1,5-a]quinoline C. Hettstedt, R. J. Mayer, J. F. Martens, S. Linert, K. Karaghiosoff,* Eur. J. Inorg. Chem. 2016, 726-735. |
Book Chapters / Non per-reviewed articles
| 2. Water, metal ions, and me: A chemist’s tale of serendipity and discovery R. J. Mayer,* Chem 2024, 10, 2342-2344. |
| 1. Mechanism and catalysis of nonenzymatic analogs of amino acid biosynthesis R. J. Mayer,* J. Moran,* Advances in Physical Organic Chemistry 2023, 57, 1-39 |
Mayer lab at Technische Universität München 